I would honestly try eliminating the duplex load, I know that fouling will be an issue, so make sure you use a good over powder wad, but just to see if it helps with the leading. Are you getting a decent lube star at the muzzle? What kind of lube are you using? I shoot a lot of cast bullets, I have gone to powder coated for everything except for my Sharps and BP.
I was thinking that the next time I try the softer bullets I have I'll go straight BP. The guy that sent them to me uses them with BP. They are the Lyman 457193 405gr. And our lubed with spg. I tried them first with the 7 grain 4227 duplex and a 0.462 wad cut from a cereal box that was 0.025 thick. Accuracy was poor, and I had leading throughout the barrel. Then I tried a 4 grain duplex with an HDPE wad at 0.025 thick. Accuracy was better, but the leading was pretty much the same. I had a greasy star at the muzzle with these bullets.
I had been thinking that the wad is supposed to protect the base of the bullet from gas cutting, deformation, melting, etc. But apparently that isn't so? So what does the wad do other than allow a person to alter the compression for a given BP charge?