My dad and I have been hunting deer with a 338 RUM for years, he had heart issues, and with the snakes in SC he didn't want to go looking for them after dark.
Sadly he passed away two years ago and I miss him every day!
Dad used only two loads that the Remington custom shop gun liked, the factory 250gr a-frames @2850fps 1/2 MOA out to 600 yards… big hole, lots of blood but he always shot them in the neck so he didn't waste meat and they never went far lol.
His favorite load that didn't kick like the 250'S was 180gr accubond over 95gr of IMR 4831( crono'd @3460fps), dad killed a ton of deer with it until his precipitous health decline about 10 years ago, when he switched to a light weight 7mm-08 140 gr accubond over 46.0 gr IMR 4350 also half moa that I had built for him.
It was alway about shot placement with the old man because he loved eating them but in the end he shared with me that he like the shorter lighted guns better because they were easy to handle in a tree or stand, but cutting coyotes in half with the "big boy" as he called it, was priceless! He never did get a shot at meer or moose but he certainly brought enough gun if one had appeared, like a big horn ram did once in MT, but that's another story… no he didn't shot it!
I've also shot a 250 lb boar here in Florida with the 180gr AB at 55yards in the front shoulders and it did not pass through! do to the expansion on its thick hide and bones, and velocity of the bullet… he hit the ground hard(like Hollywood movie sideways hard) and absorbed the -3000+flbs of energy and still ran 25 yards!!! something to think about with tougher animals with lighter faster bullets… I wouldn't have believed it, if I hadn't see it myself.