I guess all the PRS dudes shooting 250 rounds in a single match and maybe 20 in tune-up the day before are shooting sub-optimal loads. It's a wonder anybody wins.
Back when I was hot and heavy in it, I loaded 300 at a time. It would get me through one big match and one local match. My last match barrel, a .260 Rem was running the same COAL and charge at 1700 rounds. The last match I shot was an F-Class match with it which I won with the last few rounds from a 300 round batch. The last chronographing of the rifle yielded 25 FPS slowed than when the load was settled on...and still within the node. The last group fired from the rifle was a screamer group shot in front of 5 students in a precision rifle class. I also shot a paper KYL and started on the 0.25" dot and center-punched it.
I prefer to spend my time shooting and not chasing loads. When you develop a load, do it with a temp stable powder, use a jump tolerant bullet, find the biggest/widest node possible (not necessarily the fastest or the 0.125 MOA node), and anneal your brass every firing and you'll be fine.