Big Eclipse, real world as it gets. I have had, reloaded for dozens of cartridges over many batches of powders and numerous slugs (lots and manufacturers).
here is what I have found.
for match accuracy, redoing the load is imperative for the best accuracy. (sub 1/2 MOA)
for hunting, no so much. I found that when I went from batch to batch with my 270 Win, 338 W/M, 375 H&H, 45-70, 300 W/M, my POI was shifted a bit and I changed my loads to compensate for the shift in POI versus POA. in a few instances, I grouped better at the higher POI and changed my POA on the scope. only once with my 270 WIN did I ever have to totally rebrew my whole load. that is when I was told that AA 3100 was discontinued. That was a really sad day.
Now if you combine these two, which long range hunting is, then rebrewing of your load might just be the best idea or at least testing out the load with another lot# of powder. if POI and grouping are better then change the POA. IF not, then rebrew the load to mimic the last batch of powder with reducing or increasing the powder charge to hit within the an inch of the last load. I find myself doing this for my fast twist guns. (longer range) I know my 338 Lapua sure does love to stretch my effective distances farther than I am normally comfortable shooting. my light tactical sniper rifle just might become my favorite extended range hunting rifle.