As Jack O so aptly postulated and proved the 270 win will kill just about anything on planet earth. It is ideal for deer, antelope, sheep, and elk out to about 650 yards. Bullet selection and weight are critical to the application. 130 gr. for deer and antelope. 140 gr. for sheep, mule deer and caribou. 150/156+ for elk, moose and bears. I like Nosler ABLRs and swift A-frames for long range and bears, but my go to for mountain hunts and deer is either a 130 gr. Nosler Bal. Tip or a 130 gr. Berger classic hunter. I can't remember the powder charge but I use either RL15 or W760. I own two light weight hunting rigs, a tikka and a Sako, both in 270. They are the work horses in the stable for both me and my boys, have been for more than thirty years. The 270 is the ballistic twin to the 280 AI, and superior to the 308, 6.5 Creedmoor, 260, 7mm-08, and the 6.5x55(which is its European equivalent). With the new bullets available and a fast twist barrel one could make a good argument it is as good or better than the 6.5 PRC or 6.8 western. Cartridge selection is really a matter of personal preference and the 270 would be my go to do anything cartridge with the exception of the big tooth critters or those with big horns and a hole lot of bad attitude, aside from that it is nearly ideal for everything from ground hogs to elk.