Yes it's best suited for heavy for caliber cartridges. I've used it in 6-284 with 105's and 22CHeetah with 80's with amazing accuracy. Velocities were at least 100 fps slower with CHeetah vs 7828ssc or Norma MRP though. With the 300W/180 combo you can see in QL pic above 99% of powder is burnt before bullet leaves muzzle and has close to 25% ballistic efficiency. Of course that can vary depending on rifle and environment/area.Just my understanding from the notes in VV page, the N565 is meant for heavier bullets. But I never tried. Let us know how it works out. I want to evnetually get away from all the Hodgdon brands.