I have no problem getting comfortable with chassis or transitioning to and from with my non-chassis rifles. On my next build (just waiting for my barrel to arrive this week), I will be using CA's MPR chassis.
This is an interesting thread, I have an Ar10 and a Bergara HMR in 6.5 creedmoor. I know the ar10 is technically not a chassis. But with all of the adjustments in the buttock with built in monopod and same brake, It's always close but not as accurate as the HMR even though I feel the fit is comparable. I have considered the CA MPR as I like the light weight and the ability to fold the stock. In the store the fit reminds me of the Ar10. I know one is a bolt gun, one is not. I mean the deer won't notice the difference in accuracy as both are submoa. But how it feels as far as fit it does feel different. When friends have shot my AR their groups open up a little more than mine they like how it shoots and they can adjust it for each shooter some shot it better than they shot my HMR. Do you feel your more accurate with the chassis or hunting stock? I know most chassis guns are heavier 15lbs or more my HMR is about10 lbs and ar10 is about 12lbs. The scope setup with the AR is heavier too by about a lb. Just curious as the CA MPR is less than 8lbs in 300win mag there is an ultralight 300 win mag at about 6 lbs I am comparing.