WOW! I'm speechless. It has to be something thats wrong with the rifle or scope or mounts, sounds like to me for a couple reasons. First off, Tikkas come with a 1 MOA guarantee, there accurate rifles. Second 25-06 are not finicky calibers and are usually very inherantly accurate calibers in good rifles. Third you are using 2 known accurate bullets and at least 2 good well known powders IMR-4350 and RL-22. I dont know what could be going wrong, but I dont think its your loading procedure anyways. The barrels cleaned, man I"m stumped. Usually 51g-52g IMR-4350 and 100g btips shoots great for many people. Kinda universal load right there. Also 57g RL-22/100g btip is a good one, as well as 53g RL-22/115g btip. I have a lot of loads for 25-06 and different makes of bullets, weight, and different powders, as well as couple different primers tried. Try some H-4831 maybe. My winchester absolutely shows a preference for this powder over any other. My ruger shot really well with IMR-4350 and RL-22. I dont know what else to recomend. Make sure everything is tight, as usual and maybe give Tikka a call. See what they say. I sure dont want you to turn on the 25-06 yet, its a great cartridge believe me. If anythign you may have got a lemon. It happens. Happened to me with a Savage in 270 WSM. Rifle wouldn't group better then 1.25" at 100 yards with probly 50-60 different loads trhough it. SO much for my Savage being a shooter! Keep us posted on how it does and maybe some other members will chime in.