I have 3 goto rifles, one .270win usually goes out all the time, one of the others is my backup. In 270win, Nosler 150gr partition, for every critter. 30-06 Nosler 165gr Sierra Game King for every critter, .243win 95gr VLD's for every critter. Once I get a rifle/load set up and zeroed in I leave it alone. No unnecessary twirling of dials unless I'm offered a real trophy at much further than I'm zeroed for. If I want to use a different bullet I grab a different rifle. If you do in fact go the one rifle route be sure to buy a VERY good quality scope. Bouncing around between points of aim requires that the scope have dependable repeatability and return to zero. A quality that to me trumps expert quality glass. I identify my target with good binoculars.