I hunt from either Tree Stands, or Tower Stands. Both of which have a generous shelf to shoot from. I still have a few Burris and Leupold Handgun Scopes on Contenders. After getting used to Rifle Scopes, it is hard (from a Tower or Tree Stand) to get far enough away from the handgun scope using Sand Bags or a Bipod with Rear Bag.
I have Weaver Classis Extreme Scopes on my Nosler M48's. The 6.5CM has a 2.5-10X. In the 2.5-5X power range it has about as much useable eye relief as a Scout Scope. From around 6-10X you do need to choke up on the scope more. The Harrell's Radial Brake really reduces recoil. I now shoot with one hand on the grip, and the support hand on my rear squeeze bag. Recoil is no problem at all. Noise and Muzzle Blast are a different story. Plugs and Muffs combined are not a bad plan practicing.
Bob R