Just as an example, Say you're getting 20 mil's of adjustment out of the BLACK FX1000 6-26 MRAD. If you're shooting longrange you have a 20 MOA base which would bump your elevation up another 6 mrad's. Even with the 20 MOA base you won't have issues zeroing this scope at 100/200 yards.
Going to 1000 yards which it seems today is the benchmark of many longrange shooter's, the below data is rough and just to give you an idea about what would be needed to reach that distance.
.223 53 gr at 3465 fps approx 10 mil
.243 95 gr @3100 fps ~10mil
.308 168gr@2800 fps ~10mil
6.5cm 143gr @2700fps ~8.5mil
.300 win 180gr @2900fps ~9mil
These are approximations and the ammo is hunting ammo, swap out the hunting ammo for a more efficient target ammo and the mil adjustment drops from 9to 7mils..
This is just to a rough example not meant to start a firestorm over this data being approximations and not gospel.