A coyote was the first animal I shot when I had my 300 RUM built. at the time I was shooting 200 accubonds at 3100 fps. I shot the coyote at approximately 200 yards and it was absolutely devistating. It literally went through the front and ripped the right rear leg off. To say something about thier toughness, it was still alive by the time I walked over to it. It was almost dead but I finished it with a pistol. Needless to say the pelt was a shredded. that is the only experience I have shooting yotes with a RUM but my opinion is dont bother to try to save the pelts if you insist on using a rum.
I understand the "one gun" thing but is it really worth trying different bullets, powders, and re-zeroing for each. no thanks. Go buy a 204, 223 or 22-250 you will be much happier.