@300 or less you got it figured. Stay light mono for deer like 80 to 90 max and you will have a Lazer beam to 300. No need for heavy mono, a 80gr will penetrate from butt to front chest. Flat is better at that range.
Yea, when I said heavy mono, that's what I had in mind. The heaviest being the 95gr. LRX but I also know the 80gr. TTSX will more than do the trick. I know both the .243 (in at least an 8 twist) and 6 creed will handle those mono's fine for deer, I think where I had some skepticism on the 6 creed was on the lighter varmint type bullets as most of what you can find on the .243 seems like it lends itself better to that. That being said, I am a reloader, so I suppose it doesn't matter nearly as much.