Dan/GunsNgeeks started this thread asking about straight-wall cases (standard pistol cartridges).
Even the typical straight-wall cartridges are easier to shoot more accurately in a single-shot set-up, given a great trigger, free-floated forend, good optics, etc...
When you get into the specialty pistol world with rifle cartridges, it is a completely different game, as you will only give up from 150 fps-250 fps to the same cartridge in a rifle of the same chambering.
Even the typical straight-wall cartridges are easier to shoot more accurately in a single-shot set-up, given a great trigger, free-floated forend, good optics, etc...
When you get into the specialty pistol world with rifle cartridges, it is a completely different game, as you will only give up from 150 fps-250 fps to the same cartridge in a rifle of the same chambering.
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