Not all of us have access to a ballistics lab so we have to depend on accepted pressure signs, reloading manuals, chronographs results and years of experience.
But if anything is a danger to someone who handloads, it is "pet loads". I hate that term. You see shooters on this forum, and others, asking for a pet load for a certain caliber. Making a suggestion on the components that one uses and has good luck with is one thing, but if posters care about their fellow shooters they should refrain from indicating the load charge. There are handloaders who will blindly follow that recipe exactly. Sometimes with dangerous results.