Whitesheep, I think you're all over it.
I'm really suggesting that by up front picking a 'standard' seating depth(without basis), and moving on through powder adjustments only to return to seating adjustments, we've pre-conditioned the seating test results.
And this, I suspect, sways the favor to 'good enough' over 'best'..
For instance, I might pre-pick 5thou, or 25thou off, and hit on a charge with it that groups really well. If I then go back to adjusting seating, I will likely find that minor adjustments either way produce worse results. But this is because I'm now affecting the fortunate found results of my charge through tension, case volume, and distance to land changes(really chasing my tail).
What most people will see here is that it's far easier to stick with what they happened upon, and keep the seating they worked through charges with.
They would never know best seating, because they already moved past the test for it..
How many people assume jammed is a good starting point for load development?
And how could these people ever really go backwards to adjusting seating depth(often referred to as fine tuning), without mangling their tune too much to determine better seating options?
So I highly doubt they ever settle on another seating depth, without starting completely over.
What I'm suggesting is to pick a moderate charge, and determine best results with it -through seating changes. Do this right up front, and THEN move on through charges. With this, once you've hit on the best charge, you also know you're at the best seating, and so there is no reason to fiddle with either again.
Maybe the tune could be fine tuned -from here- with minor seating adjustment. But I think this is more likely to show your acceptable seating tolerance, than to provide actual gain.