I shot a pronghorn buck last year with my Dasher and a 103eldx. Shot was 298 yds. Dropped at the shot. The Dasher shoots the 103 at 2905-10 FPS. It's the only animal I've taken with that bullet, but it seems a bit explosive. Was a lot of damage on the entrance side. The 243 I think will be great on antelope. I'd recommend having the shots at 400 to 500 maybe with the 103 eldx.