You will not be able to see your impacts, so dont miss, or have a spotter with you. It will beat you up, no matter what brake. It will be much more finicky to shoot and hold tune day in day out. I build a decent amount of .338s and my customers typically expect top accuracy and aren't happy when they can only do it some of the time. Light .338s have not been too popular once they start working with them.
That said, your considering a smaller .338 and only talking medium ranges, if you stick to the lighter bullets it will be better. But I place a lot of value on seeing my hits. Not knowing what happened after a shot is not a good feeling.