To answer the OPs question first we would have to verify application and distances we are considering 'down range'. With any bullet or line of bullets there are trade offs. Although the "long range" industry has caught fire the difference in application between competition and hunting is something bullet makers must pay attention to. They are aware that MOST folks are not killing anything much past 400 yards. Several polls have been taken on this site, where I believe there are alot of accomplished, competent shooters and a very small percentage have killed anything past 600 yards. Heavy for caliber in a bullet designed for high BC will have an advantage at some point assuming bullets being compared are driven to the case potential. Heavy for cal. bullets designed to penetrate can also have a more immediate advantage assuming it is well designed. A large front driven by a long shank can make an impressive wound channel complete with smashed bones without alot of bruising or deflection. In most cases, with most hunters the classic bullets weights from traditionally twisted barrels will still work great, as good as they ever have, in fact with current production methods even better. A 165 grain Accubond from a 30-06 will still hold it's own in the game field a long ways out. To see if there is an advantage to the OPs question we would need to know what bullets he is comparing specifically and how far down range they are intended to be used.