No, not with any of the cartridges I've seen. When the first hit is bad, good chance you're gonna have a sh*tshow on your hands.The 6.5 elk looked like a neck/spinal shot... it dropped instantly. IMO a riskier shot (perhaps a slight miss to the left from wind?) than a lung shot, but it certainly worked. Hard to make definitive judgments about the suitability of the caliber from this one example... the same results would have happened with any deer-capable bullet from a centerfire rifle.
The 25-06 shot was a front quartering shot that clearly penetrated... you can see the exit wound when the elk turns to the right, and the blood sign gets larger quickly. That elk bled out from a shot that likely took out both lungs and exited just behind the diaphragm on the opposite side. The bullet performed suitably, and this is IMO a positive example.
With both of these, what would have happened if the bullet had been 6" to the right? IMO a dead elk but in the first case maybe 5 to 10 seconds on its feet, but for the second case a gut shot elk that would have run quite a ways.
Is there a margin-of-error factor that makes choosing a larger caliber with more energy a better choice? Not for when everything goes right, but when something goes wrong?