If I have new brass, I would also have a new barrel. Maybe I should not be here because 100 pcs of brass is far too low of a number for me. So I have to fire all my brass, regardless.
I am going to kill 2 birds here, fire my brass plus break in the barrel, and for the most part have a load before the barrel speeds up. You do this long enough, it becomes easier to project what will happen.
Random numbers here, just say you expect 2925fps from your combination of barrel and components after barrel beak in and all brass is fired. It can be as easy as loading for 2875fps, heck, you may not have to alter one thing.
Just say now you do have make an adjustment to your powder charge, what percentage difference will it end up being with fired brass. It is going to be minimal, your seat depth is not going to change here. Process your fired brass, load 10 of your existing load and go test, both for velocity and group size, make the adjustment now if needed.
Firing the same 10 pcs of brass 6 times just to find a load means when you are done, you now only have 90 pcs to fire till those 90 have 6 firings on them, if we are talking pure accuracy standpoint.
Finding a load with new is not some insurmountable problem. Question, what happens if you do not have your load in 100 test rds with your 10 pcs of brass, all your brass would have been fired by now.