Right, I was just using extreme examples to make the point clearer. I was not saying that caliber size and bullet weight are not important, because they are, they just need to be appropriate for the type of game. And I'm talking about similar bullet types in each caliber. If you're talking about a 50 cal muzzle loader, or pistol bullet, that bullet is probably designed to expand and create a larger wound channel at slow velocity.
Some real life numbers:
A 22 cal 55 gr bullet has about 1535 ft-lbs energy at 3540 fps.
A 7mm 180 gr has about 1535 ft-lbs energy at 1960 fps.
A 338 cal 300 gr has about 1535 ft-lbs energy at 1520 fps.
A 50 cal 750 gr Amax has 1535 ft-lbs energy at 960 fps. Yes a well placed shot will kill most animals with that, but if you miss the vitals by an inch, good luck.
The 7mm and 338 are both good calibers for game such as elk, but so many people say that you want "x" amount of energy to kill. But both at 1500 ft-lbs energy, the 7mm bullet will perform and kill better than the heavier 338, simply because it has enough velocity for the bullet to do its job, I don't care if it's a 180 Berger or a 177 Hammer