I prefer the 50g Sierra Spt vs V max. Why you ask, because the Sierra will penetrate much better on quartering shots, to and fro. especially with a MV of 4150 out of a 12-14T 22/250 AI. I have a picture where the 50g V max did not shoot a hole though a coyote's head at a distance of 320 yards as he was looking over a bush at me.
In a 243 Win for coyotes, the 80g Sierra lead tip blitz is amazing, we abandoned the 85g BTHP for this bullet as the 80 shoots flatter and transfers more shock on the coyote. We shoot the 80s with an over Book max load of IMR 4064, fed 210 at 3400 fps and when you connect on a coyote, it sounds like you just hit a block wall with a very, very loud PLOP sound!.