I think Mike has a good explanation there. I have also heard and read of people who have reloaded for a certain caliber in a number of rifles or whatnot and have had good luck with x bullet being seated x from the lands with x grains of powder. So they'll load something like that up for a different rifle and tune from there. Probably works good for them too, but they have by far more reloading experience than I have.
I found that the Berger method being referred to worked pretty good for a novice reloader like myself. I don't do a ton of it and am learning something new about it every day. When I first started the seating test, I was afraid I wouldn't have one that stood out. I had one that was above and beyond the rest. Then I loaded up my powder charges to tune and feel it out.
One thing that I found kind of weird is as I worked my way up in powder charge, my groups started to really open up. I almost quit with on last group of powder charges left. But I thought, hmmm, still no signs of pressure, lets just see what happens with these. Figured I would shoot one at the very least to see if I got pressure signs. Still ended up with no pressure signs, and the groups shrunk right up to where they were at in my seating tests. That was at 1.5gr over max, and I was quite surprised. Didn't feel the need to pour any more powder to it for performance but would have liked to have seen just how high a guy could have went.
I guess the moral of my story on that is just keep pushing through as long as it is safe in the gun. I had a buddy tell me about this happening occasionally with some of his guns where it's good, then it opens up, but then comes back in as he goes up the ladder. Just taught me to make sure I do thorough testing as I would have quit otherwise.