It very possible the 210 will give you lower ES than a 215m in your 280ai. Smaller primers usually give a more consistant ignition. That's why lapua makes .308 win cases with small rifle primer pockets as well as large rifle primer pockets.
I do have some 210's as well, and that is generally what I'd use in that size case. Some guys on the Nosler forum however have been experimenting with RL26, and are seeming to have better luck with the magnum primers on the slower powders for the 280ai. May or may not turn out to be the case. I'll have to see for myself.
Thanks for the help guys!