She'd work, 400-500 I'd be hesitant on but it will work with a well placed shot. Little room for error though! Don't care how good of a shooter you are, you need to allow for error. Normally I was shooting 300. Win mag, and had a back up 7mm mag. 2 years ago my 300 crapped out and had already let a close buddy borrow the 7mm for the same hunt as his was in with the smith. So I brought a 260. Rem for moose. It is my most accurate rifle so I wasn't worried about not being able to put one down, but I wasn't prepared to take a 500 yard shot on a moose with a 260. I've taken it out too 1100 but if anything happened while out there, at 500 yards there's a strong chance I might just wound the moose.
I'd recommened keeping yardage to a minimum or stepping up in fire power