I surely would on yotes and chucks and such. They wouldn't be my choice for a 2 day trip for PD's where I could burn thru 800-1K rounds...But for a couple days of rockchuckin where I might shoot 75-100 rounds a day for sure I would out of my hunting rifles so I could a feel as to how they fly.
I've been toting them in my 22/250AI (70's) this spring for bear, haven't found a suitable volunteer as of yet. I'll probably tote them for elk this fall as well. A 70 to the ribs and our deep freeze will be full up again