My old favorite gun was a custom 243 shooting IMR 4350 with 75gr V-max at 3350fps, Shot over 200 yotes with that gun with excellent performance before shooting out the barrel.
The new barrel is a 25" Kreiger in 6mm Rem. It likes 70gr ballistic tips with a max load of Superformance at 3824fps. It is utterly wicked on yotes, allowing dead on holds to 350yds.
Both of these are very hard on bobcats, which got me to build a 204 also.
It is a custom build with a 23" Pac-Nor 1 in 10 twist. I haven't loaded for it yet but have shot 9 yotes with the 40gr V-max factory load. I'm not terribly impressed with them, I have had 2 splash hits on a rib and shoulder blade. I just switched to the 45gr Hornady factory loads, and have killed 3 more yotes with them and none took a step. Two were shot through at least one shoulder on purpose, and they still exited without much pelt damage. I want to test it further, but I'm liking it so far.