I had several guys wanting me to do 22-250AI bbls for them about 10 years ago, so ordered in several Bartlein & Krieger sendero contour blanks, all with 1-9tw, knowing that these guys were going to load as many or more lighter bullets as any of the heavies. I talked it over with each of them, suggesting that the Hornady 75 AMax was likely going to be the limit on the upper end, and they all agreed that would suit their purposes just fine. To date, only one of them has shot-out their AI bbl, and the guy who did so was looking for an excuse to have me re-barrel that rifle in 6XC anyway. He'd shot far more 75s than anything else, and was using RL22 to push them to 3400fps. He started to experience blow-ups, and was telling me about that. I suggested he try RL17, as the pressure curve is flatter, no where near as steep as RL22's. That worked for him, and he got several hundred more rounds out of that bbl before we finally agreed it was time to re-barrel.
There's still one of those 1-9tw sendero blanks out in the shop, and I've thought about using it for myself, just never seem to get fired-up enough to do so. Same goes for the 243AI reamer I bought because a couple of younger coyote callers were wanting rifles in that chambering, knowing that with the right bullets, it would work well on antelope & deer. I already have a couple of 6XCs, two 6x47 Lapuas, three 6 Dashers, and a couple of 6 RAT rifles, and just don't see the need for a 243AI. But I have done several 223AIs, a 250 Savage AI, three 6.5x55AIs, and a 280AI for myself, and really like all of them. Even though the 223AI probably gives the smallest gain in velocity of any of the AIs I've tried, in a 7-tw bbl, it works really well with Berger or JLK 90VLDs, out to 1000yds - which really surprises shooters who've never really worked with heavy-for-caliber bullets before.