For me, the ultimate coyote gun is my 6mm Remington or equivalent. Don't get me wrong. My 220 Swift will tear a dog in pieces if the 52 Grain Match King Hits bone. However, coyotes seldom present a perfect shot. 22 calibers and smaller have a real tough time getting through a sagebrush. That being said, an 80 grain out of a 6mm/243 will get the job done. It will also have less wind drift to boot.