Thanks for all the responses!
Lots of recommendations for 22-250, seems like the classic yote caliber. I already have two 22 Creeds and love them, it's been a great improvement over 22-250 and I think if I go 22 in a bolt gun, I'll go with the 22 Creed for the extra fps, especially since I'll be giving up some with a short barrel. A fella that is a big time yote hunter that has me interested says his group mostly uses 204 Rugers with 32 VMAX with excellent results, so I'm not concerned about the need to sling a big heavy bullet, but do want a decent BC for longer range opportunities. Great feedback on the little 17.
I'm concerned about follow ups.. which has me considering the AR platform. I do have an AR10 lower.. I could do a 243 or 22 Creed upper for that platform. 6 ARC seems cool, but lacks in the speed department.
I am aware of the night time optics challenge, and have started looking at thermal and NV. Looks like I'll probably end up with two rifles, as swapping day and night optics on the same rifle doesn't seem practical.
Keep 'em coming guys! Thanks again for the comments so far