I am a 300 and in guy,most are 150 or under,have had a few runners with my 223,will say great majority of my shots are head on.Caller placement can have a lot to do with shot angles.Last runner I had was in New Mexico a few weeks ago,he went about 60 yards as I shot him a little far back but the 53 grain V MAX got the job done.My 223 is running 3300 fps while my 250 is 3600 with 55 grain V MAX.If one caliber was the absolute best there would only be one left.Lots of calibers work if you hit the sweet spot.Tons of deer killed here in Okla with a 223,me included in that group.Main thing is enjoy whatever you get.Coyotes are most fun in the world in my books,guess that is why I have loved it so much since 1972.