I say .300 Winchester or 7mm Rem Mag just because of the vast amounts of ammo and components out there for them. If you go out West and forget to grab your shells, any place that sells ammunition will have .300 WIN or 7mm RM. Less common cartridges like .300 Weatherby, .300 RUM, 7mm STW, and 28 Nosler are all good big game rounds, but the possibility of finding ammo for them, in a pinch, will be difficult. When you do begin to start reloading, brass and data for both the .300WM and 7mm Remington Mag can be found easily and brass is cheaper for them compared to some of the other magnums.