I agree with a lot that has been said here. Just my own experience to go off of. I had a long range shooting class (instructed by a former Marine sniper) last week using my 6.5-284 Norma and 7 STW. Both rifles zeroed at 200 yards and both have hand loads with single digit ES/SD and velocities verified the day before. No issues noticed until we got out to 650-1060 yards. In my 6.5, I am shooting the 140 gr Berger hunting VLD. It was consistently high by 2 moa at the longer distances, which we really noticed at 885. Using the instructors Kestrel, he said either the velocity increased from 2980 fps to 3200 fps, or the BC is off. He plugged in G7 of .363 from .307 (listed on the Berger box) to get everything to align. It was dead on the next 10 shots as far as vertical was involved. If I missed, it was now due to an incorrect wind dope. As you can see, that's a huge difference in BC from what is actual compared to what is on the box of bullets.
In contrast, the BC of the 175 gr ELDX I'm shooting in my 7 STW was correct and no adjustments were needed.
I have a field shooting follow up course in a few days, and I'm going to verify the BC for the Berger bullets. I want to make sure that it wasn't caused by the ambient temperature (it was 103 degrees) and/or a hot barrel.
What I'm taking away from this experience is that you really need to verify your drops once you get out to and beyond 500 yards. So, I'll have data for these 2 rifles, but I'll need to test all my other rifles if I ever want to stretch them out to longer ranges. For now, I'm not going to shoot any game animal past 500 yards, unless it's with my 6.5 or 7mm and the situation is perfect. I always try to get as close as possible.