A few points.... I reload exclusively, no factory ammo for me. Had a 300WSM 30-06, 308 and 444 in the past, so not new to big(er) recoil, but at some point the joy of shooting diminishes. I'm often drawn to "different" cartridges, and when someone asks me what I'm shooting it's kind of nice to throw something out there that no one has heard of; 444, 41mag, 356gnr for example.
So far 280ai is really calling my name. For me researching the cartridge is half the fun of getting a new gun. This will be the most expensive gun in my collection so far, so I want to do it right.