the Bergers do well for me. I shoot a 338 @ 2800 MV a 300 win @ 2995 MV. These velocities are at 4100 ft alt. I would have no issues shooting the bergers from either of my rifles at a big elk at 50 yards. The crease right behind the shoulder is the key for a highly expandable bullet at close range.
What I mean by "know your bullet" is this. down below 1900 fps it may not open at all. This is where the Berger shines as a long range bullet. At the same time if you are shooting a fragmenting bullet at close range from a rifle sending them out above 3000 fps I would not go for a heavy boned placement at 50 yards.
No two shots are ever the same, ever! The bullet speed, angle, placement,caliber, bullet weight, animal size, did it contact bone first, meat first all make a difference. There are instances where every or any bullets can fail. But was it the bullet that failed, or the shooter for not knowing his bullet and rig?
I hunt elk in the mountains. I want elk down as soon s possible. This is why I shoot Bergers. If the shot is close they go down in a few steps if they take any at all. If the shot is long I can depend on the bullet to expand and do damage. On the longer pokes they usually hunch up, stand there for a brief time wobble and fall over.
Hope this answers your question.
Jeff