Having shot both with what would be a recommended bullet for that specific caliber, I find the kick of the 375 pushes harder but doesn't have the sharpness of that of the 338. I was bothered by neither while hunting moose or caribou. I haven't a desire to shoot a bear (no problem with anyone else wanting to) and have, in fact, accompanied friends on bear hunts - thus the larger caliber rifle. I would imagine that the adrenaline flow received when readying for a shot at a big bear would drown out any concern for kick. I've never noticed kick when shooting a game animal, and frequently use my 340 Wby for whitetail.