Unless you specify best
at what this is nothing more than begging for an argument between people with vastly different goals.
Best at making .100" groups from a bench?
Best for a 7 year old to use schwacking does under the feeder at 50 yards?
Best for shooting an elk at 600 yards when it's -15* outside?
Best at making a cold bore shot at a mile?
Best at ****ing off everyone who thinks differently than you do?
Some things are worth shooting 0.2 gn increments of 5-10 shots per weight. Somethings I just shoot until there are pressure signs and back off a grain to shoot as few rounds as possible. Some things I shoot whatever the book spits out as a middle load and never change the powder weight at all. Those are all the best ways for each of those situations for me; if they weren't I'd do something differently.
For anyone curious, the answers are: 38 clicks on my Harrel with LT-30, half a case of H4895 behind a 125gn SST in 30-06, anything with a magnum primer over at least 90gns of powder, anything loaded into a 6.5 Creedmoor, and BC doesn't matter just shoot it faster.