OP mentioned 180 TSX back in the day. I no longer shoot a 300 WM but when I did I was killing elk and mulies with 190 Berger's. I never tried anything else because they shot so well. I now find myself being an armchair quarterback and a fence sitter. I can't argue with the terminal results of the Berger's, because they killed everything I pointed them at. With that, I never really liked the way they did it. There was so much fragmentation if bullet and none that any bullet placed anywhere near a shoulder resulted in lost meat. Again, it anchored critters without issue.
Now I shoot a 7 RM and purposely worked on different recipes of Barnes bullets. The 150 TTSX shoot 1/2 minute and match my BDC Reticle perfectly out to 700 (top of post on my vx6). It also shoots the 139 LRX really well, but not a perfect match to my reticle. I chose the Barnes after reading about so many folks trusting them in Africa. I have no intentions of going to Africa but relying on accounts from folks that have seems like a good place to start. Elk are tough animals, possibly among the toughest to take down in NA (everyone says moose die easily and don't run as far, Browns/grizz seem to just roll over unless they are trying to eat you, but elk can suck up some punishment).
This year, after my Alaska blacktail Hunt I decided to do some more practicing before my elk hunt. I shot up all of my 150 loads so I loaded 60 more. Went back out to verify that these loads matched my last and things were NOT good. Groups were all over the place. Some shots showed pressure even though I hadn't adjusted powder or any other variables. With no time to figure out what the issue was, I bought a few boxes of factory 139 LRX (150 TTSX sold out - go figure). Verified drops at range and decided I'd just limit myself to 400 since I didn't have time to really get settled in and confident with the sudden mid-season switch. Shot my bull at 360. I hit him top 1/3 of lungs on shot 1, just behind shoulder. He didn't go down so I hit him again, just under spine. That dumped him and he died. I was happy with the performance and nonexistent meat loss.
I also shot a black bear, blacktail and mulie with the-50 TTSX this year, all one shot hits. I'm very pleased with Barnes. They don't have the sexy BC of Berger's but they are effective.
Just my $.02