Your powder charge stands to make the most change in your results.
This is not true.
It is unlikly that ANY powder change will affect grouping as much as seating depth changes can.
OP your best to stick with Berger's plan using any mid power load, and then tweak it right into the best seated results(regardless of what they are). With this, you can move into load development, including primer testing, ladder testing or OCW.
Best seating with a particular bullet and chamber is just that.
It doesn't change with powder load, but best powder load does change a bit with seating. So get your seating right first and avoid the tail chasing.
It's the same with primers. Seat them the same in fireformed brass(FF'd with seating checks) & find the primer, or adjust striking for the primer that produces lowest ES with a mid power load(again regardless of the raw result). Then move on to powder, as it is actually a smaller adjustment(with a good scale).
Then if off the lands, move on to neck tension tweaking to shape the group(smallest adjustment).
From largest to smallest in logical order.
Be sure to get the barrel up to foul & stable temps before testing. Time your shot rate and avoid transitions/changes that invalidate your testing.