In the case of the 6.5-284 I mentioned, in a 10 mph wind at 300 yds there is a difference of .6 mils from 9 to 3, that equates to about 6.5 inches. That folks is not insignificant. Speed the wind up to 20 mph and it gets crazy. Granted, the effects are not this drastic in rounds with high BC bullets and/or extremely high velocities.
Even for the mighty 375 Cheytac shooting SMKs, at 1000 yds in a 10 mph wind, AB shows a difference of .29 mils, that equates to a difference around 10 inches, again, a significant amount. Increase the wind to 20 mph, now the difference is .58 mils which equates to a difference of around 21 inches.
If AB is correct, no cartridge is exempt from significant effects of ADJ.