Bravo 4, A great post, as are all posts on this thread, by the way, they hit many nails on the head. This whole idea of "setback" as a concept to evaluate whether to tote (for example) a 300 WBY or a 30-06 or a 26 somethingorother got started when I was elk hunting a'horseback in the Frank Church the second time, in 2014. Our very, very experienced outfitter would not allow any guns under a .308 caliber (not 308 NATO, rather, "thirty caliber") because he did not want to be chasing wounded elk on the Middle Fork of the Salmon country. He was OK with a 30-06 but not with anything smaller, and he limited 30-06 to 300-400 yard shots (horizontal; the bull I shot on our second trip was 300 yards on the rangefinder but only 150 horizontally, it is some steep country.) So it got me to thinking, what exactly is the difference between a 300 WSM and a 30-06 and a Wby 300, setback-wise? Turns out it is not that far, with a lot of bullets; and a good long way with some others. The magnums seem to benefit from the newer high BC for caliber bullets even more than the "standard" cartridges, especially if you reload; and with the wildcats, all bets are off. And as the Hornady data I set out demonstrated, there are some myths out there about the "incredible power" of certain cartridges that may not be that accurate.
Of course, as the 6.5 Creedmoor mania demonstrates, just because it is a wildcat doesn't make it a miracle pill. Not enough gun remains not enough gun, especially in those situations like Orange Dust set out above. That is where the energy at range information can help, for those not-so-easy or even (let's face it) bad shots.
But ultimately, as we all know, it is the shooter, and the technique, not the gun. Heck, Eskimos used to hunt polar bears with 22s. Makes for a dandy sucking chest wound, and not enough noise to rile the bear up.