It's hard to discount the performance of an accurate match barrel that seems to shoot every bullet and every combination of powder well. But, if you accept the theory that you should select a powder that fills the case and still offers accuracy and velocity with a given bullet weight, then your list of suitable powders gets a little shorter.
For whatever reason, I have had very satisfactory results using 100% and compressed charges of H4831 in a number of rifles from 220Swift to 300 magnums.
Of course, there are exceptions. Some people use 3031 or 4895, substantially faster powders with a lot of air space, and are happy.
I always have some IMR4350 on hand. I find it to be especially useful in 243 and 6mmRem. with certain bullet weights.
But, when you are using heavy for caliber bullets in a 300 Mag. (as Fiftydriver already mentioned) then 4350 appears to be a little on the fast side, as to burning rate. Fast powders and heavy bullets are not usually your best choice. Everything being relative.
Once you factor in your barrel length, there may be a reason to go with a faster powder? For instance, say your barrel was only 22", the slow burning 4831 might produce a huge flame of unburnt powder and no velocity advantage. The 4350 may peak in the shorter barrel, and could be the best choice, strictly considering velocity. But, if you have enough barrel length to support the H4831 burning rate, then I'd say it deserves consideration.
I personally don't use R22 in anything but 25 caliber, so can't comment on that. But, the reason is that I find H4831 to be superior in every yardstick of performance that it would just waste my time. (as you said, each rifle is different) If I were developing a load right now, (which I'm not) I would have to consider it, as well as VV and Norma powders.
To me, IMR 4350 doesn't seem to work, on paper, for your application, but if it does, who can argue? The only way to find out......after you get your other problem resolved, is on the bench.
Good hunting. LB
edit: I just noticed your other post. For what it's worth, I have always used a Win.8½ large rifle primer in 300 Winchester. The Fed 215M with a hotter spark may allow the 4350 to burn even faster, I don't know? Mag primers are a good choice for sub zero temperatures, though.
[ 09-24-2004: Message edited by: LB ]