I'm an original big game hunter with 25-06 and killed piles of deer, pigs and a couple bulls with .257 cal bullet. I also trailed a few. I also lost two deer to marginal hits at dark. Lessons learned. After I melted the barrel down on the 25-06, I went up slightly to 270 WSM. Wow was it a killer on deer. Better blood trails and no lost animals. I also bought a lever gun as I am a lefty in 308 Marlin Express. Shoots a 160 grain bullet at a methodical 2600 fps. I noticed bigger blood trails and animals being dead even with less than ideal hits. So I had my kids and friends shoot it. As kids often get excited they jerk the trigger and bullets hit animals in all kinds of wild locations. Despite liver shots, shots in the hams, spine hits or lower brisket, the animals all died. Blood loss being the cause of death. So as much as I love my super fast 25-06 and that little .257 cal bullet I can honestly say that if you hit a game animal in a less than desirable position I feel the larger caliber has a better chance of eventually killing that animal. I've witnessed over 300 game animals killed over my 30 years of hunting and the bigger diameter bullets come in contact with more tissue, more blood vessels, make bigger holes and stuff just dies. I still shoot that 270 wsm today and a 280 AI. But if I'm after elk I take my 300 wm with 200 grain bullets. Stuff doesn't always go to plan and I just like having that insurance plan of the big slug. Every day I hear shot placement blah blah blah yeah well what happens when we're off by 3 inches, or misjudge the wind, your range finder dies and you have to estimate distance. You hunt long enough and kill enough animals and you're gonna have bad hits. It's just hunting and nobody is perfect. I take the largest gun I can shoot well. 30 years, 9 states, 2 continents and over 200 big game animals killed personally, that is just my opinion and field data observations. The only animals I've ever lost were inexperienced hunters that made bad hits with 243, 257 and 6.5 calibers. To me I feel 243 and 257 and 6.5 are seasoned hunters rifles. They know how to control buck fever and have good shooting skills. For a kid, or beginning hunter I always have them shoot a 7mm-08 or 308. I love Jack O'Conner but Elmer Keith was definitely on to something.