snox,
From those that said the 435 grainers BC wasn't very good, what are the numbers they are using. I haven't seen or heard anything, been waiting on Applied Ballistics to put some numbers out as well. The furthest I've shot the 375 grain version was 1337 yards and used .8 G1. Looking at the 435 & 375 next to each other my guess is the BC is over .86 G1. Now this isn't great when compared to the CE bullets in this weight class, but still not bad. What needs to happen is for Berger to put out a high BC VLD (not lathed turned).
I can understand your concerns about having to seat them out so far as to not use it as a repeater, and maybe wanting another barrel for the long really high BC projectiles. Mine was chambered (and twist rate) the opposite, more along the lines of the 350 Matchkings and other cup-n-core bullets. I also have a longer 36"/1-8" twist barrel I want to chamber for the longer bullets, thought about a larger chambering as well. I don't know if my rifle can push the 435's fast enough to have as good of down range performance as the 375's.