I seem to have a long term running "gun battle" with a long time friend about this very thing.. he has a 300 Win Mag. he wants to use 200+ grain slugs in it and has discounted everything I have ever told him about long range accuracy and 1:10" twist rates. from what I used to do for a hobby, 1,000 and 1 mile competitions, I would never use over a 190 grain for the 1,000 yard and 1 mile comps as the slug would go unstable if I used anything heavier. my best advice and the same advice I gave him.. do not use anything over a 175 grain VLD ELD slug in a 1:10" twist rate. If you go heavy, go with a 1:8" or 1:7" twist rate. I do not care what it states on the box.. after 600 yards, maybe 800 yards the 200+ grain slugs go unstable in flight. What every combination you decide to use.. do not use 1:10" twist rate barrels for those heavy slugs, 200 - 240 grain.
most all reamer MFGR's I know require a special order for the long VLD/ELD slug throats.