If you're using 150 gain bullets, consider trying H4895. I used one of the 4350s for all bullet weights I loaded for the .30-06 (150 -180 grains) for around fifty years. Several years ago, I tried H4895 with my favorite .30-06 bullet, the Barnes 150 TTSX BT. Accuracy was already good with H4350, but it improved slightly with H4895 and velocity was only a little less than what I was getting with a full (maybe compressed, I don't remember) charge of one of the 4350s. However, H4895 is a little too fast for bullets heavier than 150 grains in the .30-06 if you want the highest velocity.