First, check your barrel twist to be sure you can stabilize the bullets you want to try. Then research the terminal ballistics of each and measure that against your philosophy of use (i.e., what are you hunting). If long range shooting/hunting is a concern, research typical velocities of each bullet and mode it in a ballistic computer (BC) like JBM or Hornady 4dof to see which bullet gives you the longest effective range (velocity above the transonic zone - about 1400fps) or less wind drift. Generally, heavy for caliber bullets are more aerodynamic and yield longer effective ranges than lighter faster bullets. Don't concern yourself with bullet drop, that is easily and accurately calculated by any BC. However, during terminal ballistics research, you may find that the bullet with the longest effective range is terminally ineffective at a velocity much higher than the transonic barrier and that extra range is useless to you.