Shot a cow @ 250 yards last fall with my .340 and 225 gr Nosler E-Tip. Very accurate bullet and devastating hit. 2 broken ribs with lots of splinters therefrom causing massive internal chest damage, and a nice hole out the other side. Bang-flop. Load was 80 gr of N160, but I get great results with many powders. As long as you can shoot it accurately, better to be a bit overgunned than under!