Let me put it this way. I have only killed 6 coyotes with a 22 mag. None ran far. All were shot inside 50 yards. Most spun around and died on the spot. I have killed 1 with a 17 HMR. 100 yards. It was a pass through the ribbs. I was surprized the17g bullet went all the way through. Coyote went 10 yards. Hey if a 22mag is all you have, pick your shots, hit them right and it will do the job. No, it is not a center fire,but it will kill them at 100 yards, better at 50. Coyote hunting I would rather use my K Hornet or 223 or 22-250 or my 220 Swift. Depends on the terrain and what I feel like at the time. Some guy on U Tube shot lots of coyotes with his 22 mag 10 -22 mag. He went with the 22mag because of mounting the camera on the rifle and the recoil didn't kill his camera. He had to shoot some of them several times to bring them down.